Modalert & Armodafinil Dosage Guide
This dosage module provides a clear overview of commonly referenced dosing patterns for modafinil and armodafinil products including Modalert 200, Modvigil 200, Artvigil 150, and Artvigil 250. The information below summarizes typical label-aligned dosing patterns used in sleep-medicine contexts.
1. Quick Mapping by Molecule
| Molecule | Products |
|---|---|
| Modafinil 200 mg | Modalert 200, Modvigil 200 |
| Armodafinil (R-modafinil) | Artvigil 150, Artvigil 250 |
2. Dosage by Condition
| Condition | Modafinil (Modalert 200 / Modvigil 200) | Armodafinil (Artvigil 150 / Artvigil 250) |
|---|---|---|
| Narcolepsy | 200 mg once daily (morning) | 150–250 mg once daily (morning) |
| OSA-related excessive sleepiness | 200 mg once daily (morning) | 150–250 mg once daily (morning) Note: No consistent evidence that 250 mg provides additional benefit beyond 150 mg in OSA. |
| Shift Work Disorder (SWD) | 200 mg once daily ~1 hour before shift | 150 mg once daily ~1 hour before shift |
3. Dosage by Product
| Product | Molecule | Strength | Typical Label-Aligned Use Pattern |
|---|---|---|---|
| Modalert 200 | Modafinil | 200 mg | 200 mg morning (Narcolepsy / OSA) or 200 mg ~1 hour before shift (SWD) |
| Modvigil 200 | Modafinil | 200 mg | Same as above (modafinil 200 mg) |
| Artvigil 150 | Armodafinil | 150 mg | 150 mg morning (Narcolepsy / OSA) or 150 mg ~1 hour before shift (SWD) |
| Artvigil 250 | Armodafinil | 250 mg | 250 mg morning fits within label range for Narcolepsy / OSA; SWD dose remains 150 mg ~1 hour before shift |
Detailed Instructions
A) When to Take It (Timing)
If used for Narcolepsy or OSA-related sleepiness:
- Take once daily in the morning.
If used for Shift Work Disorder (SWD):
- Take once daily approximately 1 hour before the start of the work shift.
B) Food / Empty Stomach
- Modafinil is generally described as being taken with or without food in major clinical references.
- If specific food interactions are mentioned in prescribing information, follow those instructions.
C) Dose Range Notes
Modafinil (Modalert 200 / Modvigil 200)
- The commonly referenced recommended dose is 200 mg once daily for narcolepsy and OSA.
- For Shift Work Disorder, the same 200 mg once daily approximately 1 hour before the shift is commonly referenced.
Armodafinil (Artvigil)
- Narcolepsy / OSA: 150–250 mg once daily in the morning.
- Doses up to 250 mg/day have been tolerated, but research notes that additional benefit beyond 150 mg/day is not consistently observed in OSA.
- SWD: 150 mg once daily approximately 1 hour before the shift.
D) Missed Dose
- If it is close to your normal dosing time, take the dose when remembered.
- If it is already late in the day, skip the missed dose and continue the next day.
- Avoid taking doses late in the day as it may affect nighttime sleep.
E) Special Populations
Modafinil
- In cases of severe hepatic impairment, dose reduction to approximately half the recommended dose may be considered.
- Geriatric patients may require lower starting doses depending on clinical evaluation.
Armodafinil
- Dose adjustments may also be considered in hepatic impairment or elderly populations according to prescribing references.
Note: The information above summarizes dosing patterns described in clinical references and prescribing information. Individual dosing decisions should be based on professional medical guidance.